abstract：:Dietary intervention is the first treatment step in management of hyperlipidaemia, but there are few objective criteria of compliance. Whether intensive dietary intervention would produce a detectable change in erythrocyte membrane fatty acid composition which could be used as a marker of compliance was examined in 31...

journal_title：Atherosclerosis

authors： Tynan MB,Nicholls DP,Maguire SM,Steele IC,McMaster C,Moore R,Trimble ER,Pearce J

更新日期：1995-10-01 00:00:00

abstract：:We determined the effects of different dialysis conditions on the antioxidant content, duration of the lag phase and oxidation rate of LDL. Dialysis for 22 h resulted in a 56%--66% reduction in the concentrations of beta-carotene, lycopene and alpha-tocopherol. The lag phase of copper-induced oxidation of freshly isol...

journal_title：Atherosclerosis

authors： Scheek LM,Wiseman SA,Tijburg LB,van Tol A

更新日期：1995-09-01 00:00:00

abstract：:Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...

journal_title：Atherosclerosis

authors： Bates EJ,Ferrante A,Smithers L,Poulos A,Robinson BS

更新日期：1995-08-01 00:00:00

abstract：:We examined the interactive effect of oxidized low density lipoprotein (LDL) and ascorbic acid on collagen production in cultured smooth muscle cells (SMCs). Porcine aortic SMCs were incubated with 50-200 micrograms/ml of human LDL with/without 5 microM Cu2+ for 24 h. Collagen production was assayed by successive salt...

journal_title：Atherosclerosis

authors： Jimi S,Saku K,Uesugi N,Sakata N,Takebayashi S

更新日期：1995-07-01 00:00:00

abstract：:Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobar...

journal_title：Atherosclerosis

authors： Toborek M,Kopieczna-Grzebieniak E,Drózdz M,Wieczorek M

更新日期：1995-06-01 00:00:00

abstract：:This report concerns a heart transplant patient with hypercholesterolemia who showed rapid development of a severe transplant coronary artery disease. The patient received 10 mg pravastatine per day. Quantitative coronary angiography analyses of 4 serial angiograms clearly demonstrated that in the first 2.5 years foll...

journal_title：Atherosclerosis

authors： Park JW,Vermeltfoort M,Braun P,May E,Merz M

更新日期：1995-05-01 00:00:00

abstract：:The effect of cage population density on plasma lipids and the development of atherosclerosis was examined in female C57BL/6 mice. Mice were housed at a density of one, two or five animals per cage and fed an atherogenic diet for 28 weeks. Subsequently, the animals were bled, sacrificed, the hearts removed and the ext...

journal_title：Atherosclerosis

authors： Lin AH,Castle CK,Melchior GW,Marotti KR

更新日期：1995-05-01 00:00:00

abstract：:We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...

journal_title：Atherosclerosis

authors： Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

更新日期：1995-04-24 00:00:00

abstract：:HDL has been shown to enhance the removal of cholesterol from cultured fibroblasts, smooth muscle cells and macrophages, but fails to stimulate cholesterol removal from J-774 macrophages. Since J-774 macrophages do not synthesize or secrete apolipoprotein E, the effect of exogenous apolipoprotein E on HDL-mediated cel...

journal_title：Atherosclerosis

authors： Granot E,Eisenberg S

更新日期：1995-04-07 00:00:00

abstract：:Known cytochrome P450-dependent oxygenase inhibitor ketoconazole (5-50 microM) blocked the murine macrophage-mediated modification of human low density lipoprotein (LDL) as measured by production of thiobarbituric acid-reactive substance, stimulation of [125I]LDL degradation in a fresh set of macrophages and LDL elect...

journal_title：Atherosclerosis

authors： Dushkin MI,Zenkov NK,Menshikova EB,Pivovarova EN,Lyubimov GYu,Volsky NN

更新日期：1995-04-07 00:00:00

abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...

journal_title：Atherosclerosis

authors： Opper C,Clement C,Schwarz H,Krappe J,Steinmetz A,Schneider J,Wesemann W

更新日期：1995-03-01 00:00:00

abstract：:The association between cardiorespiratory fitness (VO2max) and carotid atherosclerosis was analyzed in 163 men, aged 50 to 60 years. VO2max was assessed using breath-by-breath respiratory gas analyses during maximal exercise stress test. Atherosclerosis was evaluated quantitatively as intima-media thickness (IMT) of t...

journal_title：Atherosclerosis

authors： Rauramaa R,Rankinen T,Tuomainen P,Väisänen S,Mercuri M

更新日期：1995-01-20 00:00:00

abstract：:The intravascular metabolism of cholesteryl [1-14C]oleoyl ester and [1,2-3H(N)]cholesteryl palmityl ether was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). The tracers had identical plasma disappearance rates when they were incorporated into human or rat low density ...

journal_title：Atherosclerosis

authors： Terpstra AH

更新日期：1995-01-06 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) is implicated in the pathogenesis of atherosclerosis. In this study the susceptibility to oxidation of LDL (from patients with atherosclerosis) is related to the progression of the disease. LDL were isolated from 37 patients with demonstrable atherosclerotic plaques. The susc...

journal_title：Atherosclerosis

authors： Andrews B,Burnand K,Paganga G,Browse N,Rice-Evans C,Sommerville K,Leake D,Taub N

更新日期：1995-01-06 00:00:00

abstract：:The effects of administration of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on hepatic cholesterol 7 alpha-hydroxylase and acyl-coenzyme A: cholesterol acyltransferase (ACAT) activities and bile lipid secretion were investigated in Syrian golden hamsters. Continuous administrat...

journal_title：Atherosclerosis

authors： Hayashi K,Noshiro M,Kurushima H,Kuga Y,Nomura S,Ohkura Y,Ohtani H,Kurokawa J,Tanaka K,Yasunobu Y

更新日期：1994-12-01 00:00:00

abstract：:We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary ...

journal_title：Atherosclerosis

authors： Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

更新日期：1994-10-01 00:00:00

abstract：:Atherosclerosis is the most frequent complication of diabetes. There are many potentially atherogenic factors in diabetes that may underlie this problem. Of these, one is the group of dyslipoproteinemias. In diabetes there are both qualitative and quantitative changes in the plasma lipoproteins. Based on pathophysiolo...

journal_title：Atherosclerosis

authors： Steiner G

更新日期：1994-10-01 00:00:00

abstract：:Estrogen use is associated with protection from cardiovascular disease in postmenopausal women. This benefit appears to be magnified among women with pre-existing heart disease. The possible bias of intrinsically better health in women using estrogen has not been ruled out in observational studies. Therefore, two doub...

journal_title：Atherosclerosis

authors： Knopp RH,Zhu X,Bonet B

更新日期：1994-10-01 00:00:00

abstract：:Atherosclerosis is characterised by unusual growth of vascular smooth muscle cells (VSMCs) in the intima. We examined the effects of histamine on human VSMCs and the VSMC-derived cell line, ISS10. Histamine enhanced phosphoinositide hydrolysis, increased cytoplasmic Ca2+ level and stimulated the transcription of c-fos...

journal_title：Atherosclerosis

authors： Satoh T,Sugama K,Matsuo A,Kato S,Ito S,Hatanaka M,Sasaguri Y

更新日期：1994-09-30 00:00:00

abstract：:Chylomicron retention disease (CRD) is a rare autosomal recessive disorder characterized by the absence of post-prandial chylomicrons and apolipoprotein (apo) B-48 in sera from affected individuals. Apo B-100 is synthesized, and apo B-100-containing lipoproteins are present in sera. A crucial difference between the sy...

journal_title：Atherosclerosis

authors： Patel S,Pessah M,Beucler I,Navarro J,Infante R

更新日期：1994-08-01 00:00:00

abstract：:Cholesterol lowering in both primary and secondary prevention has been clearly demonstrated to lower coronary morbidity and, in secondary prevention, to lower coronary mortality as well. Putative dangers of cholesterol lowering remain unproven. Population studies linking low cholesterol to noncoronary mortalities do n...

journal_title：Atherosclerosis

authors： LaRosa JC

更新日期：1994-08-01 00:00:00

abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...

journal_title：Atherosclerosis

authors： Miller VT

更新日期：1994-08-01 00:00:00

abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

journal_title：Atherosclerosis

authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

更新日期：1994-07-01 00:00:00

abstract：:The spatial distribution of intimal thickening was determined for each of 42 carotid bifurcations removed at autopsy from patients with no clinical or anatomic evidence of cerebrovascular disease. Both right and left specimens were available for six of the individuals. Each bifurcation was removed intact and included ...

journal_title：Atherosclerosis

authors： Masawa N,Glagov S,Zarins CK

更新日期：1994-06-01 00:00:00

abstract：:The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole...

journal_title：Atherosclerosis

authors： Clark P,Cockburn F,Cowan RA,Czapla K,Dunnigan MG,Farish E,Hughes E

更新日期：1994-05-01 00:00:00

abstract：:The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

journal_title：Atherosclerosis

authors： Terpstra AH

更新日期：1994-04-01 00:00:00

abstract：:The relations between triglyceride-rich lipoproteins, alimentary lipaemia and coronary heart disease (CHD) have remained obscure and much debated. We studied the basal and postprandial plasma levels of chylomicron remnants and very low density lipoproteins (VLDL) of varying particle size in 32 male postinfarction pati...

journal_title：Atherosclerosis

authors： Karpe F,Steiner G,Uffelman K,Olivecrona T,Hamsten A

更新日期：1994-03-01 00:00:00

abstract：:High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by many cells without parallel uptake of HDL apolipoproteins. This selective uptake of HDL CE was investigated in human monocyte-derived macrophages (HMM). HDL3 (d = 1.125-1.21 g/ml) was labeled in its apolipoprotein A-I moiety with 125I and in its CE...

journal_title：Atherosclerosis

authors： Rinninger F,Deichen JT,Jäckle S,Windler E,Greten H

更新日期：1994-02-01 00:00:00

abstract：:To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (apo E) and B (apo B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control group...

journal_title：Atherosclerosis

authors： Kervinen K,Savolainen MJ,Salokannel J,Hynninen A,Heikkinen J,Ehnholm C,Koistinen MJ,Kesäniemi YA

更新日期：1994-01-01 00:00:00

abstract：:The primary objective of this study was to determine the variability in cholesterol carrying capacity of low density lipoproteins (LDLs) and other apolipoprotein B (apo B)-containing lipoproteins in normolipidemic men. One hundred and fifty-nine normolipidemic men, ages 21 to 73 years, were enrolled. In addition to de...

journal_title：Atherosclerosis

authors： Abate N,Vega GL,Grundy SM

更新日期：1993-12-01 00:00:00

abstract：:The prevalence of coronary heart disease (CHD), cardiovascular disease (CVD) and associated risk factors was studied in 413 men aged 70-89, the survivors of the Finnish cohorts of the Seven Countries Study. Men were divided into five categories according to manifestations of prevalent CVD: I, history or ECG evidence o...

journal_title：Atherosclerosis

authors： Tervahauta M,Pekkanen J,Kivinen P,Stengård J,Jauhiainen M,Ehnholm C,Nissinen A

更新日期：1993-12-01 00:00:00

abstract：:To clarify age-related and lipid-related hemostatic abnormalities in the elderly, we measured the plasma levels of active PAI-1 antigen (aPAI-1), tPA-PAI-1 complex (TPC), plasminogen, alpha 2-plasmin inhibitor (alpha 2-PI), plasmin-alpha 2-PI complex (PIC), and D-dimer, together with the plasma levels of fibrinogen, f...

journal_title：Atherosclerosis

authors： Kario K,Matsuo T

更新日期：1993-11-01 00:00:00

abstract：:The mechanism(s) by which doxazosin, an alpha 1 inhibitor, regulates plasma low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) levels were investigated in 'normocholesterolemic' (average total cholesterol (TC) of 218 mg/dl) and 'hypercholesterolemic' (average TC of 350 mg/dl) cynomolgus monkeys. ...

journal_title：Atherosclerosis

authors： Stucchi AF,Vespa DB,Terpstra AH,Nicolosi RJ

更新日期：1993-11-01 00:00:00

abstract：:The effect of different fat loads on postprandial lipemia and hemostatic activity was examined in 10 middle-aged men using 3 different meals. One meal was rich in saturated fatty acids (cream), the other rich in n-6 polyunsaturated fatty acids (sunflower oil) and the third was fat-free containing only carbohydrates. L...

journal_title：Atherosclerosis

authors： Salomaa V,Rasi V,Pekkanen J,Jauhiainen M,Vahtera E,Pietinen P,Korhonen H,Kuulasmaa K,Ehnholm C

更新日期：1993-10-01 00:00:00

abstract：:The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel el...

journal_title：Atherosclerosis

authors： Zhao SP,Verhoeven MH,Vink J,Hollaar L,van der Laarse A,de Knijff P,van 't Hooft FM

更新日期：1993-09-01 00:00:00

abstract：:Hyperapobetalipoproteinemia (hyperapo B), a common disorder associated with coronary artery disease, is characterized by an increased number of small, dense, low density lipoprotein (LDL) particles. The cellular mechanisms responsible for early atherosclerosis in hyperapo B are unknown. We tested the hypothesis that h...

journal_title：Atherosclerosis

authors： Kafonek SD,Raikhel I,Bachorik PS,Kwiterovich PO Jr

更新日期：1993-08-01 00:00:00

abstract：:In the rabbit, dietary cholesterol downregulates the hepatic LDL receptor and concomitant treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors partly restores its expression. The aim of this study was to determine whether the LDL receptor activity of circulating mononuclear cells would r...

journal_title：Atherosclerosis

authors： Roach PD,Kerry NL,Whiting MJ,Nestel PJ

更新日期：1993-07-01 00:00:00

abstract：:We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....

journal_title：Atherosclerosis

authors： Ueda Y,Arai H,Kawashima A,Nagano Y,Cho M,Tanaka M,Kita T

更新日期：1993-06-01 00:00:00

abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

journal_title：Atherosclerosis

authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

更新日期：1993-05-01 00:00:00

abstract：:Blood pressure elevation is frequently associated with elevated cholesterol, triglyceride or low density lipoprotein (LDL-C) or low high density lipoprotein (HDL-C). The relative importance of genetic and environmental factors in these associations is unclear. We examined the relative contribution of genetic and envir...

journal_title：Atherosclerosis

authors： Williams PD,Puddey IB,Martin NG,Beilin LJ

更新日期：1993-04-01 00:00:00